The role of the gut microbiome in the healthy adult status
The role of the gut microbiome in the healthy adult status
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DOI：
10.1016/j.cca.2015.01.003
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发表时间：
2015-12-07
影响因子：
5
通讯作者：
Salvatore, Francesco
中科院分区：
文献类型：
--
作者：
D'Argenio, Valeria;Salvatore, Francesco
肠道微生物组包含多达1000种细菌，编码约500万个基因，执行宿主生理和生存所需的许多功能。因此，它也被称为“我们被遗忘的器官”。下一代测序技术的最新发展极大地改善了宏基因组学研究。特别是，它增加了我们对微生物组及其与人类宿主互利关系的了解。微生物在出生后立即开始定植。虽然受到各种刺激的影响，即饮食，身体活动，旅行，疾病，激素周期和治疗，但微生物组在健康成年人中实际上是稳定的。这表明微生物组在成年期维持健康状态方面发挥着作用。肠道微生物组组成的定量和定性变化可能导致病理性生态失调，并与越来越多的肠道和肠外疾病有关。随着对肠道微生物组功能的了解的增加，越来越有可能开发基于微生物组操作的新型诊断，预后和最重要的治疗策略。(C)2015年，作者。由爱思唯尔公司出版
The gut microbiome, which hosts up to 1000 bacterial species that encode about 5 million genes, perform many of the functions required for host physiology and survival. Consequently, it is also known as "our forgotten organ". The recent development of next-generation sequencing technologies has greatly improved metagenomic research. In particular, it has increased our knowledge about the microbiome and its mutually beneficial relationships with the human host. Microbial colonization begins immediately at birth. Although influenced by a variety of stimuli, namely, diet, physical activity, travel, illness, hormonal cycles and therapies, the microbiome is practically stable in healthy adults. This suggests that the microbiome plays a role in the maintenance of a healthy state in adulthood. Quantitative and qualitative alterations in the composition of the gut microbiome could lead to pathological dysbiosis, and have been related to an increasing number of intestinal and extra-intestinal diseases. With the increase in knowledge about gut microbiome functions, it is becoming increasingly more possible to develop novel diagnostic, prognostic and, most important, therapeutic strategies based on microbiome manipulation. (C) 2015 The Authors. Published by Elsevier B.V.