Motility-Driven Glass and Jamming Transitions in Biological Tissues
Motility-Driven Glass and Jamming Transitions in Biological Tissues
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DOI：
10.1103/physrevx.6.021011
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发表时间：
2016-04-21
影响因子：
12.5
通讯作者：
Manning, M. Lisa
中科院分区：
文献类型：
--
作者：
Bi, Dapeng;Yang, Xingbo;Manning, M. Lisa
致密组织内的细胞运动控制着许多生物学过程，包括胚胎发育和癌症转移，最近的实验表明这些组织表现出集体玻璃化行为。为了对组织中的玻璃化转变进行定量预测，我们研究了一种自推进的Voronoi模型，该模型同时捕获融合组织中的极化细胞运动和多体细胞-细胞相互作用，其中细胞之间没有间隙。我们证明，该模型表现出的干扰过渡从类固体状态到类流体状态，这是由三个参数控制：单细胞运动速度，单细胞轨道的持续时间，和目标形状指数，其特征在于细胞间粘附和皮质张力之间的竞争。与传统的颗粒玻璃相比，我们能够确定一个实验上可访问的结构序参数，指定整个堵塞表面作为模型参数的函数。我们证明了一个连续软玻璃流变模型精确地捕捉到这种过渡的小持续时间的限制，并解释它是如何失败的大持续时间的限制。这些结果为理解在胚胎发育和癌症进展中观察到的集体固体到液体的转变提供了一个框架，这可能与这些组织中的上皮细胞到间充质细胞的转变有关。
Cell motion inside dense tissues governs many biological processes, including embryonic development and cancer metastasis, and recent experiments suggest that these tissues exhibit collective glassy behavior. To make quantitative predictions about glass transitions in tissues, we study a self-propelled Voronoi model that simultaneously captures polarized cell motility and multibody cell-cell interactions in a confluent tissue, where there are no gaps between cells. We demonstrate that the model exhibits a jamming transition from a solidlike state to a fluidlike state that is controlled by three parameters: the single-cell motile speed, the persistence time of single-cell tracks, and a target shape index that characterizes the competition between cell-cell adhesion and cortical tension. In contrast to traditional particulate glasses, we are able to identify an experimentally accessible structural order parameter that specifies the entire jamming surface as a function of model parameters. We demonstrate that a continuum soft glassy rheology model precisely captures this transition in the limit of small persistence times and explain how it fails in the limit of large persistence times. These results provide a framework for understanding the collective solid-to-liquid transitions that have been observed in embryonic development and cancer progression, which may be associated with epithelial-to-mesenchymal transition in these tissues.