Evolutional perspective and functional characteristics of interleukin-17 in teleosts
Evolutional perspective and functional characteristics of interleukin-17 in teleosts
复制标题
DOI：
10.1016/j.fsi.2022.108496
复制
发表时间：
2022-12-20
影响因子：
4.7
通讯作者：
Hikima，Jun-ichi
中科院分区：
文献类型：
--
作者：
Okamura，Yo;Kono，Tomoya;Hikima，Jun-ichi
白细胞介素（IL）-17是一种促炎细胞因子，在针对细菌和真菌感染的适应性和先天性免疫应答中发挥重要作用。特别是在哺乳动物粘膜组织中，众所周知，通过IL-17 A和IL-17 F的先天免疫应答，例如抗微生物肽的产生，对于微生物群控制非常重要。与此相反，有趣的见解，IL-17的功能，最近有报道在几个硬骨鱼物种，虽然很少有研究已经进行了硬骨鱼IL-17。在本综述中，我们重点介绍了目前对硬骨鱼IL-17的认识，并推测了硬骨鱼IL-17信号传导与哺乳动物不同或一致的部分。本文综述了硬骨鱼IL-17在肠道免疫中的作用。我们希望，这一审查将鼓励进一步了解的作用和IL-17信号在硬骨鱼的重要性。
Interleukin (IL)-17 is a proinflammatory cytokine and plays essential roles in adaptive and innate immune responses against bacterial and fungal infections. Especially in mammalian mucosal tissues, it is well known that innate immune responses via IL-17A and IL-17F, such as the production of antimicrobial peptides, are very important for microbiota control. In contrast, interesting insights into the functions of IL-17 have recently been reported in several teleost species, although little research has been conducted on teleost IL-17. In the present review, we focused on current insights on teleost IL-17 and speculated on the different or consensus parts of teleost IL-17 signaling compared to that of mammals. This review focuses on the role of teleost IL-17 in intestinal immunity. We expect that this review will encourage a further understanding of the roles and importance of IL-17 signaling in teleosts.