Hypothalamic Astrocytes in Obesity
Hypothalamic Astrocytes in Obesity
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DOI：
10.1016/j.ecl.2012.11.003
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发表时间：
2013-03-01
影响因子：
4.5
通讯作者：
Tschoep, Matthias H.
中科院分区：
文献类型：
--
作者：
Garcia-Caceres, Cristina;Yi, Chun-Xia;Tschoep, Matthias H.
肥胖的特征是包括下丘脑在内的组织中的慢性低度炎症。下丘脑炎症被认为是肥胖发病的早期和决定性因素，甚至在体重增加之前就已经发生了。在下丘脑内，小胶质细胞和星形胶质细胞产生细胞因子，驱动炎症反应。星形胶质细胞直接受到营养过剩的影响，并可能在促进肥胖患者下丘脑炎性反应方面发挥独特的作用。本文综述了支持下丘脑星形胶质细胞在肥胖中的作用的证据，并提出了一种新的神经内分泌研究方法，旨在揭示肥胖的发病机制和开发新的治疗策略。
Obesity is characterized by a chronic and low-grade inflammation in tissues including the hypothalamus. Hypothalamic inflammation is considered an early and determining factor for the onset of obesity, a factor that occurs even before body weight gain. Within the hypothalamus, microglia and astrocytes produce cytokines that drive inflammatory responses. Astrocytes are directly affected by nutrient excess and might play a unique role in promoting hypothalamic inflammatory responses in obesity. This article reviews evidence supporting the role of hypothalamic astrocytes in obesity, and suggests a new approach for neuroendocrine research designed to reveal pathogenesis and develop novel treatment strategies against obesity.