The innate immune response in human tuberculosis.
The innate immune response in human tuberculosis.
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DOI：
10.1111/cmi.12480
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发表时间：
2015-09
影响因子：
3.4
通讯作者：
Gutierrez MG
中科院分区：
文献类型：
--
作者：
Lerner TR;Borel S;Gutierrez MG
结核分枝杆菌（Mtb）感染可以在适应性免疫应答开始之前被先天免疫系统清除。这种先天性保护需要来自许多不同宿主免疫细胞类型的多种稳健的细胞自主应答。然而，结核分枝杆菌已经发展出规避其中一些防御的策略。在这篇小型综述中，我们讨论了这些宿主-病原体相互作用，重点是在人类细胞中进行的研究和/或由人类遗传学研究（如全基因组关联研究）支持的研究。
M ycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini‐review, we discuss these host–pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome‐wide association studies).