The impact of rate of weight loss on body composition and compensatory mechanisms during weight reduction: A randomized control trial
The impact of rate of weight loss on body composition and compensatory mechanisms during weight reduction: A randomized control trial
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DOI：
10.1016/j.clnu.2017.04.008
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发表时间：
2018-08-01
影响因子：
6.3
通讯作者：
Martins, Catia
中科院分区：
文献类型：
--
作者：
Coutinho, Silvia Ribeiro;With, Emilie;Martins, Catia
背景和目标：快速体重减轻（WL）与去脂体重的大量减少和静息代谢率（RMR）的不成比例降低有关，但证据并不确定。我们的目的是评估WL率的影响，身体成分和补偿机制激活WL（减少RMR，增加运动效率（ExEff）和食欲），无论是在负能量和中性energy balance（EB）.Methods：35名肥胖的参与者被随机分配到失去类似的体重迅速（4周）或逐渐（8周），之后保持它（4周）。体重和组成、RMR、ExEff（10、25和50 W）、食欲感觉和食欲调节激素在基线和每个阶段后，测量空腹和每30分钟直至2.5小时的活性生长素释放肽、胆囊收缩素、总肽YY（PYY）、活性胰高血糖素样肽-1和胰岛素。两组的体重（约9%）和组成变化相似。随着WL，仅快速WL组的RMR降低，10 W时的ExEff显著增加。然而，空腹饥饿增加了显着的渐进WL，而空腹和餐后预期的食物消费量，和餐后饥饿减少（和餐后饱胀增加）显着的快速WL。基础总PYY、基础和餐后胰岛素显著降低，两组相似。体重稳定后，没有酮症组之间没有差异被发现。结论：尽管差异，而在负EB，WL率似乎并没有显着影响身体成分或代偿机制，一旦EB重建。(C)2017 Elsevier Ltd和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: Rapid weight loss (WL) has been associated with a larger loss of fat free mass and a disproportional reduction in resting metabolic rate (RMR), but the evidence is inconclusive. We aimed to evaluate the impact of WL rate on body composition and compensatory mechanisms activated with WL (reduced RMR, increased exercise efficiency (ExEff) and appetite), both during negative and neutral energy balance (EB).Methods: Thirty-five participants with obesity were randomized to lose a similar weight rapidly (4 weeks) or gradually (8 weeks), and afterwards to maintain it (4 weeks). Body weight and composition, RMR, ExEff (10, 25 and 50 W), appetite feelings and appetite-regulating hormones (active ghrelin, cholecystokinin, total peptide YY (PYY), active glucagon-like peptide-1 and insulin), in fasting and every 30 min up to 2.5 h, were measured at baseline and after each phase.Results: Changes in body weight (approximate to 9%) and composition were similar in both groups. With WL, RMR decreased and ExEff at 10 W increased significantly in the rapid WL group only. However, fasting hunger increased significantly with gradual WL only, while fasting and postprandial prospective food consumption, and postprandial hunger decreased (and postprandial fullness increased) significantly with rapid WL only. Basal total PYY, and basal and postprandial insulin decreased significantly, and similarly in both groups. After weight stabilization and no ketosis no differences between groups were found.Conclusions: Despite differences while under negative EB, WL rate does not seem to have a significant impact on body composition or on compensatory mechanisms, once EB is reestablished. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.