A clinical and pathological study in patients with sudden unexpected death in Epilepsy
A clinical and pathological study in patients with sudden unexpected death in Epilepsy
复制标题
癫痫患者猝死的临床与病理研究
DOI：
10.1186/s42494-019-0007-5
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发表时间：
2019-11
影响因子：
--
通讯作者：
Lü Yang
中科院分区：
文献类型：
--
作者：
Yu Weihua;Zhu Ying;Li Qingshu;Tian Xin;Zhang Peng;Lü Yang
背景癫痫猝死（sudden unexpected death of epilepsy，SUDEP）是癫痫的一种严重后果。本研究旨在报告SUDEP患者的临床和病理学表现。当死亡原因符合SUDEP定义时，分析临床和病理资料。结果8例患者因全身强直阵挛性发作死亡，5例患者因情绪变化诱发发作，4例死于床上。6例患者服用卡马西平。尸检显示所有11名患者均出现脑水肿和肺水肿。SUDEP受试者的部分脑中存在神经元丢失和神经胶质增生。SUDEP的主要病理改变包括脑水肿、肺水肿、神经元丢失和胶质增生。结论SUDEP的危险因素为全身强直阵挛发作、情绪障碍和卡马西平治疗。
BackgroundSudden unexpected death of epilepsy (SUDEP) is a severe outcome of epilepsy. This study aimed to report the clinical and pathological findings in patients with SUDEP.MethodsThe record of patients with sudden death was screened. When the reason of death matched with the definition of SUDEP, the clinical and pathological data were analyzed. Eleven patients with SUDEP were included in the study.ResultsEight patients died after a generalized tonic-clonic seizure, seizures were induced by emotional changes in five patients, four cases were found dead in bed. Carbamazepine was prescribed in six patients. The autopsy showed brain edema and pulmonary edema in all eleven patients. Loss of neurons and gliosis were presented in some brains of SUDEP subjects. The main pathological changes in SUDEP include brain edema, pulmonary edema, loss of neurons and gliosis.ConclusionsRisk factors for SUDEP in the study are generalized tonic-clonic seizure, emotional disturbance and carbamazepine treatment.
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影响因子：
1.2
作者：
B. Morentin;R. Alcaraz
通讯作者：
B. Morentin;R. Alcaraz
DOI：
10.1056/jn199908010000002
发表时间：
1999
期刊：
NEJM Journal Watch
影响因子：
--
作者：
S. Schachter
通讯作者：
S. Schachter
影响因子：
2.6
作者：
Jake Swinghamer;O. Devinsky;D. Friedman
通讯作者：
Jake Swinghamer;O. Devinsky;D. Friedman
影响因子：
5
作者：
Maria Thom;S. Seetah;S. Sisodiya;Matthias J Koepp;Francesco Scaravilli
通讯作者：
Maria Thom;S. Seetah;S. Sisodiya;Matthias J Koepp;Francesco Scaravilli
影响因子：
5.6
作者：
Nashef, L
通讯作者：
Nashef, L