The inflammatory Th 17 subset in immunity against self and non-self antigens
The inflammatory Th 17 subset in immunity against self and non-self antigens
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DOI：
10.1080/08916930701776605
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发表时间：
2008-01-01
期刊：
影响因子：
3.5
通讯作者：
Zhao, Yong
中科院分区：
文献类型：
--
作者：
Jin, Di;Zhang, Lianjun;Zhao, Yong
传统上认为辅助性T细胞（Th细胞）基于其细胞因子谱分化成Th 1和Th 2亚群。最近，已经鉴定了以与Th 1或Th 2细胞不同的方式发育和发挥功能的白介素（IL）-17产生细胞（Th 17细胞）的亚群。Th 17细胞已被证明在诱导自身免疫组织损伤、炎症和感染中起关键作用。Th 17亚群及其相关问题的研究为自身免疫性疾病、癌症、感染和移植等疾病的治疗提供了潜在的靶点，对临床免疫相关疾病的预防和/或治疗具有重要意义。
T helper cells (Th cells) are traditionally thought to differentiate into Th1 and Th2 subsets based on their cytokine profiles. Recently, a subset of interleukin (IL)-17-producing cells (Th17 cells) which develop and function in a distinct way from Th1 or Th2 cells has been identified. Th17 cells have been shown to play a crucial role in the induction of autoimmune tissue injuries, inflammation and infection. Studies on Th17 subset and its relevant issues offered potential therapeutic targets for patients with autoimmune diseases, cancer, infection and transplant, which may have significant impacts in the prevention and/or treatment of immunity-related diseases in clinics.