FAT (FAT) AND TUBBY (TUB) - 2 AUTOSOMAL RECESSIVE MUTATIONS CAUSING OBESITY SYNDROMES IN THE MOUSE
FAT (FAT) AND TUBBY (TUB) - 2 AUTOSOMAL RECESSIVE MUTATIONS CAUSING OBESITY SYNDROMES IN THE MOUSE
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DOI：
10.1093/oxfordjournals.jhered.a111019
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发表时间：
1990-11-01
影响因子：
3.1
通讯作者：
EICHER, EM
中科院分区：
文献类型：
--
作者：
COLEMAN, DL;EICHER, EM
这份报告描述了由两个常染色体隐性突变引起的小鼠肥胖综合征的发展，位于8号染色体上的脂肪（fat）和位于7号染色体上的tubby（tub）。这两种突变都会导致缓慢发展但最终严重的肥胖症。虽然高胰岛素血症、β-胰岛素分泌亢进、胰岛素分泌功能亢进，胰岛细胞，以及β-细胞脱颗粒是一致的特征，这些肥胖综合征不会发展为严重的糖尿病。小鼠中产生不同严重程度的肥胖-糖尿病综合征的许多不同的单基因突变使突变小鼠成为分析可能导致肥胖状态的主要缺陷的数量和性质的有力工具。
This report describes the development of obesity syndromes in mice caused by two autosomal recessive mutations, fat (fat), located on chromosome 8, and tubby (tub), located on chromosome 7. Both mutations cause slowly developing but ultimately severe obesity conditions. Although hyperinsulinemia, hyperactivity of the .beta. cell of the islets of Langerhans, and .beta.-cell degranulation are consistent features, these obesity syndromes do not progress to severe diabetes. The many different single-gene mutations in the mouse that produce obesity-diabetes syndromes of varying degrees of severity make the mutant mouse a powerful tool for analyzing the number and nature of the primary defects than can cause obesity states.