Torsades de pointes complicating atrioventricular block:: Evidence for a genetic predisposition
Torsades de pointes complicating atrioventricular block:: Evidence for a genetic predisposition
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DOI：
10.1016/j.hrthm.2006.10.004
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发表时间：
2007-02-01
期刊：
影响因子：
5.5
通讯作者：
Rodriguez-Lafrasse, Claire
中科院分区：
文献类型：
--
作者：
Chevalier, Philippe;Bellocq, Chloe;Rodriguez-Lafrasse, Claire
背景在完全性房室传导阻滞合并长QT综合征（LQTS）的情况下，遗传危险因素的流行率尚未得到系统评估。目的：本研究旨在确定在房室传导阻滞的背景下获得性LOTS在多大程度上具有遗传底物。方法：在420例植入起搏器3年以上的患者中，我们回顾性地确定了29例完全性房室传导阻滞和QT间期>600 ms的患者。第二个研究组包括22名随机选择的患有房室传导阻滞和QT间期的患者
BACKGROUND The prevalence of genetic risk factors has not been systematically evaluated in the setting of complete atriventricular (AV) block complicated by Long QT syndrome (LQTS).OBJECTIVE This study was performed to determine to what extent acquired LOTS in the context of AV block has a genetic substrate.METHODS Among 420 recipients of pacemakers implanted over a 3-year period, we identified retrospectively 29 patients with complete AV block and a QT interval >600 ms in duration. A second study group included 22 randomly selected patients who had AV block and a QT interval