Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study.
Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study.
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较高的心包肥胖与普遍的糖尿病有关：年轻人研究的冠状动脉风险发展。
DOI：
10.1016/j.numecd.2015.12.011
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Carr JJ
中科院分区：
文献类型：
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作者：
Alman AC;Jacobs DR Jr;Lewis CE;Snell-Bergeon JK;Carnethon MR;Terry JG;Goff DC Jr;Ding J;Carr JJ
心包脂肪组织（PAT）位于心包两侧。我们在年轻人冠状动脉风险发展（CARDIA）研究的25年检查中测试了PAT是否与流行糖尿病有关。CARDIA第25年检查（2010-2011）包括3107名参与者的所有协变量的完整数据。流行糖尿病（n=436）被定义为空腹高（≥126 mg/dl）或负荷后2小时血糖（≥200 mg/dl）或HbA1c（≥6.5%）或使用糖尿病药物。通过计算机断层扫描测量PAT的体积。采用Logistic回归检验PAT四分位数与糖尿病的关系。在校正了场地中心、性别、种族、年龄、收缩压、总胆固醇、对数甘油三酯以及降压和降胆固醇药物治疗的回归模型中，调整BMI （OR 2.57, 95% CI 1.66, 3.98）或内脏脂肪组织（OR 2.08, 95% CI 1.32, 3.29）后，第4四分位数的PAT体积与糖尿病状态显著相关。相对于第一个四分位数，第二和第三四分位数的PAT体积与糖尿病状况没有显著相关性。代谢活跃的心包脂肪组织仅在体积较大时与糖尿病相关，与总体肥胖无关。
Pericardial adipose tissue (PAT) is located on both sides of the pericardium. We tested whether PAT was associated with prevalent diabetes at the year 25 exam of the Coronary Artery Risk Development in Young Adults (CARDIA) study. The CARDIA Year 25 exam (2010-2011) included complete data for all covariates on 3107 participants. Prevalent diabetes (n=436) was defined as high fasting (≥126 mg/dl) or 2-hour postload glucose (≥200 mg/dl) or HbA1c (≥6.5%) or use of diabetes medications. Volume of PAT was measured from computed tomographic scans. Logistic regression was performed to examine the relationship between quartiles of PAT and diabetes. In regression models adjusted for field center, sex, race, age, systolic blood pressure, total cholesterol, log triglycerides, and treatment with blood pressure and cholesterol lowering medication, PAT volume in the 4th quartile was significantly associated with diabetes status after adjustment for BMI (OR 2.57, 95% CI 1.66, 3.98) or visceral adipose tissue (OR 2.08, 95% CI 1.32, 3.29). PAT volume in the 2nd and 3rd quartiles was not significantly associated with diabetes status relative to the first quartile. Metabolically active pericardial adipose tissue is associated with prevalent diabetes only at higher volumes independent of overall obesity.