Gene targeting in embryonic stem cells scores a knockout in Stockholm
Gene targeting in embryonic stem cells scores a knockout in Stockholm
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DOI：
10.1016/j.cell.2007.11.033
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发表时间：
2007-12-14
期刊：
影响因子：
64.5
通讯作者：
Mak, Tak Wah
中科院分区：
文献类型：
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作者：
Mak, Tak Wah
2007年诺贝尔生理学或医学奖授予马里奥·卡佩基、马丁·埃文斯和奥利弗·史密斯，以表彰他们开发了特定的基因修饰技术和小鼠胚胎干细胞技术，当这些技术结合在一起时，能够创造出“基因敲除”小鼠。对这些突变动物的分析彻底改变了基因功能的阐明，这些小鼠已被证明是许多人类疾病的有价值的模型。
The 2007 Nobel Prize in Physiology or Medicine has been awarded to Mario Capecchi, Martin Evans, and Oliver Smithies for developing specific gene modification techniques and mouse embryonic stem cell technology that, when combined, enable the creation of "knockout" mice. Analyses of these mutant animals have revolutionized the elucidation of gene functions, and these mice have proved to be valuable models of numerous human diseases.