Pyrrolizidine alkaloids from Heliotropium rotundifolium.
Pyrrolizidine alkaloids from Heliotropium rotundifolium.
复制标题
来自圆叶天芥菜的吡咯里西啶生物碱。
DOI：
10.1021/np50064a010
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发表时间：
1989
影响因子：
5.1
通讯作者：
Zalkow,LH
中科院分区：
文献类型：
--
作者：
Asibal,CF;Gelbaum,LT;Zalkow,LH
除了先前分离出的欧洲碱[1]外，圆叶天芥菜还含有三种其他生物碱：从该植物中分离得到一种新的生物碱，命名为5 ′-乙酰基乌洛平[4]，并通过波谱方法确定了其结构（1H和1H-bC HETCOR NMR和MS），物理性质（熔点和/或旋光度），与真实样品的比较，肝毒性吡咯里西啶生物碱（PA）作为人类中毒的可能原因越来越受到关注（1）。除了存在于一些传统草药中之外，它们也是一些食品中的低水平污染物。吡咯里西啶生物碱具有广泛的药理活性，因此对其进行了广泛的研究。
Heliotropium rotundifolium was shown to contain, in addition to the previously isolated europine [1], three other alkaloids: heliotrine [2], lasiocarpine [31, and a new alkaloid identified as 5'-acetyleuropine [4], The alkaloids were isolated by dccc and the structures established by spectroscopic means ('H and'H-bC HETCOR nmr and ms), physical properties (melting points and/or optical rotations), comparison with authentic samples, or by semi-synthesis.The hepatotoxic pyrrolizidine alkaloids (PAs) are of increasing concern as possible causes of human poisoning (1). Besides their presence in some traditional herbal medicines, they are also low-level contaminants in some foodstuffs. The broad range of pharmacological activity associated with pyrrolizidine alkaloids has continued to gen-erate extensive studies on these compounds.