Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.
Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.
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DOI：
10.1161/circulationaha.120.049922
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发表时间：
2021-05-25
期刊：
影响因子：
37.8
通讯作者：
Majesky MW
中科院分区：
文献类型：
--
作者：
Miano JM;Fisher EA;Majesky MW
血管平滑肌细胞（VSMC）长期以来与表型调节/可塑性或去分化有关。细胞谱系追踪、单细胞RNA测序和人类基因组学方面的创新技术已被整合，以获得对实验和临床动脉粥样硬化中VSMC向其他细胞表型的分子重编程的前所未有的见解。目前的想法是，收缩性VSMC的一个明显的小子集经历了向过渡性多潜能细胞的命运转换，这些细胞可以采用斑块去稳定化（炎症、骨化）或斑块稳定化（胶原基质沉积）细胞状态。这种VSMC的命运和状态变化的几个候选介质即将曝光与理解冠状动脉疾病的风险和新的治疗方式的发展耐人寻味的影响。在这里，我们简要总结了一些技术和概念上的进步，来自两个出版物在循环和另一个在自然医学，共同照亮新的研究方向，以进一步探讨血管平滑肌细胞在动脉粥样硬化疾病中的作用。
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single cell RNA-sequencing, and human genomics have been integrated to gain unprecedented insights into the molecular reprogramming of VSMCs to other cell phenotypes in experimental and clinical atherosclerosis. The current thinking is an apparently small subset of contractile VSMCs undergoes a fate switch to transitional, multi-potential cells that can adopt plaque de-stabilizing (inflammation, ossification) or plaque-stabilizing (collagen matrix deposition) cell states. Several candidate mediators of such VSMC fate and state changes are coming to light with intriguing implications for understanding coronary artery disease risk and the development of new treatment modalities. Here, we briefly summarize some technical and conceptual advancements derived from two publications in Circulation and another in Nature Medicine that, collectively, illuminate new research directions to further explore the role of VSMCs in atherosclerotic disease.