Temporal and spatial events in the calcium messenger system.
Temporal and spatial events in the calcium messenger system.
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钙信使系统中的时间和空间事件。
DOI：
10.1007/978-1-4684-7618-7_2
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发表时间：
1987
影响因子：
--
通讯作者：
Barrett,P
中科院分区：
文献类型：
--
作者：
Rasmussen,H;Barrett,P
中枢神经系统的巨大复杂性使它成为生物化学研究的一个困难的对象。然而，对细胞调控领域有影响的一些最重要的生化发现已经在中枢神经系统组织中取得。Nishizuka及其同事在脑组织中发现了一种新的蛋白激酶，即所谓的磷脂依赖性钙活化蛋白激酶或c激酶（Takai et al.）。该激酶被发现不同于经典的camp依赖性或ca++ - cam依赖性蛋白激酶。然而，发现它可以被钙、磷脂和二酰基甘油激活（Takai et al., 1977; Kishimoto et al., 1980）。在大脑中发现大量存在后，人们发现它广泛分布于动物组织中（Nishizuka和Takai， 1981）。它的发现与我们对肌醇多磷酸酶在钙信使系统中发生的转导事件中的作用的理解的重大突破相吻合（michel, 1975; Berridge, 1984）（见本卷中Agranoff和Lapetina的章节）。
The great complexity of the central nervous system makes it a difficult object of biochemical study. Yet, some of the most important biochemical discoveries having implications for the field of cell regulation have been made in CNS tissue. A case in point is the discovery by Nishizuka and coworkers of a new kind of protein kinase, the so-called phospholipid-dependent, calcium-activated protein kinase or C-kinase, in brain tissue (Takai et al.). This kinase was found to be distinct from either the classic cAMPdependent or Ca++-CaM-dependent protein kinases. It was, however, found to be activated by Ca++, phospholipids, and diacylglycerols (Takai et al., 1977; Kishimoto et al., 1980). After its discovery in the brain, where it exists in very large amounts, it was found to be widely distributed in animal tissues (Nishizuka and Takai, 1981). Its discovery coincided in time with a significant breakthrough in our understanding of the role of inositol polyphosphatase in the transducing events which occur in the calcium messenger system (Michell, 1975; Berridge, 1984) (see chapters by Agranoff and by Lapetina in this volume).