Nuclear architecture and radiation induced chromosome aberrations: Models and simulations
Nuclear architecture and radiation induced chromosome aberrations: Models and simulations
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DOI：
10.1093/oxfordjournals.rpd.a006756
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发表时间：
2002-01-01
影响因子：
1
通讯作者：
Ottolenghi, A
中科院分区：
文献类型：
--
作者：
Ballarini, F;Biaggi, M;Ottolenghi, A
辐射轨迹结构及其相互作用的知识，以生物目标作为理解生物损伤诱导机制的基本出发点。在这种情况下，蒙特卡罗代码是一个强大的调查工具，允许一个模拟轨道结构和功能的目标（S）在不同的尺度。从纳米（DNA的线性尺寸）到微米（人类细胞核和间期染色体区域的线性尺寸），根据最近的实验发现，关于核结构。不同的方法在染色体结构和畸变诱导建模进行了讨论。尤其是。提出了一个模型，其中染色体区域被明确地描述为亚核区域，畸变诱导通过耦合靶结构与辐射径迹结构来模拟。模型预测和文献中的实验结果之间的比较也有报道。
Knowledge of radiation track structure and its interaction, with biological targets as a fundamental starting point in understanding the mechanisms underlying the induction of biological damage. In this context Monte Carlo codes are a powerful tool of investigation, allowing one to Simulate both track structure and the features of the target(s) of interest at different scales. from nanometres ( linear dimensions of DNA) to micrometres (linear dimensions of human cell nuclei and interphase chromosome territories), In the light of recent experimental finding, on nuclear architecture. different approaches in modelling chromosome structure and aberration induction are discussed. In particular. a model is presented in which chromosome territories were explicitly described as subnuclear regions and aberration induction was modelled by Coupling the structure of the target with that of the radiation track. Comparisons between model predictions and experimental results from the literature are also reported.