The research on kinetics of interaction between selectin and ligand in inflammatory processes
The research on kinetics of interaction between selectin and ligand in inflammatory processes
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发表时间：
2006
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通讯作者：
Ye Zhi-yi;Quan Xue-jun
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作者：
Ye Zhi-yi;Quan Xue-jun
白细胞在炎症和血栓形成过程中沿毛细血管后小静脉内皮细胞滚动。介导白细胞在血管内皮细胞上滚动的细胞黏附分子家族有P-选择素、E-选择素和L-选择素。选择素与其相应的配体--P-选择素糖蛋白配体-1的相互作用是非常重要的。
Leukocytes roll along the endothelium of postcapillary venules in response to inflammatory and thrombotic processes.The se- lectin family of cell adhesion molecules,which mediate the rolling of leukocytes on blood vessel endothelium,are the P-selectin,E-selectin and L-selectin.It is very important for selectins to interact on their counterpart ligand-P-selectin glycoprotein ligand-1(PSGL-1).Kinet- ics interactions between selectin and PSGL-1 was extensively studied by using the state-of-the-art techniques such as surface plasma reso- nance,flow chamber,atomic force microcope(AFM)and so on.