Single-Cell Microgels for Diagnostics and Therapeutics
Single-Cell Microgels for Diagnostics and Therapeutics
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DOI：
10.1002/adfm.202009946
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发表时间：
2021-03-26
影响因子：
19
通讯作者：
Darling, Eric M.
中科院分区：
文献类型：
--
作者：
Dubay, Ryan;Urban, Joseph N.;Darling, Eric M.
水凝胶液滴内的细胞封装正在改变生物医学多个领域的可行性，如组织工程和再生医学、体外建模和基于细胞的治疗。最近的进展使研究人员能够将材料封装复合物缩小到单细胞尺度，其中每个复合物被称为单细胞微凝胶，仅包含一个被水凝胶基质包围的细胞
Cell encapsulation within hydrogel droplets is transforming what is feasible in multiple fields of biomedical science such as tissue engineering and regenerative medicine, in vitro modeling, and cell-based therapies. Recent advances have allowed researchers to miniaturize material encapsulation complexes down to single-cell scales, where each complex, termed a single-cell microgel, contains only one cell surrounded by a hydrogel matrix while remaining