Structures of the colossal RyR1 calcium release channel
Structures of the colossal RyR1 calcium release channel
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DOI：
10.1016/j.sbi.2016.09.002
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发表时间：
2016-08-01
影响因子：
6.8
通讯作者：
Hendrickson, Wayne A.
中科院分区：
文献类型：
--
作者：
Clarke, Oliver B.;Hendrickson, Wayne A.
Ryanodine 受体 (RyR) 是细胞内阳离子通道，可介导肌浆网 (SR) 快速大量释放 Ca2+，以满足心肌和骨骼肌兴奋收缩耦合的需要。由于高分辨率冷冻电子显微镜 (cryoEM) 重建和骨骼肌受体 RyR1 多种功能状态的相关原子模型的发表，在过去两年中，对 RyRs 的结构和门控的理解取得了显着进展。在这里，我们回顾了对 RyR 架构和门控理解的最新进展，并强调了我们预计很快将填补的理解上的空白。
Ryanodine receptors (RyRs) are intracellular cation channels that mediate the rapid and voluminous release of Ca2+ from the sarcoplasmic reticulum (SR) as required for excitation contraction coupling in cardiac and skeletal muscle. Understanding of the architecture and gating of RyRs has advanced dramatically over the past two years, due to the publication of high resolution cryo-electron microscopy (cryoEM) reconstructions and associated atomic models of multiple functional states of the skeletal muscle receptor, RyR1. Here we review recent advances in our understanding of RyR architecture and gating, and highlight remaining gaps in understanding which we anticipate will soon be filled.