A STRONG NEGATIVE ASSOCIATION BETWEEN ALCOHOL-CONSUMPTION AND THE RISK OF HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC-PATIENTS - A CASE-CONTROL STUDY
A STRONG NEGATIVE ASSOCIATION BETWEEN ALCOHOL-CONSUMPTION AND THE RISK OF HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC-PATIENTS - A CASE-CONTROL STUDY
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DOI：
10.1007/bf01719346
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发表时间：
1994-06-01
影响因子：
13.6
通讯作者：
DIORIO, F
中科院分区：
文献类型：
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作者：
ARICO, S;CORRAO, G;DIORIO, F
我们开展了一项以医院为基础的病例对照研究，以评估乙肝病毒感染和终生每日饮酒与肝硬变患者发生肝细胞癌的风险之间的关系。病例为62例连续住院的消化科患者，首次诊断为肝细胞癌合并LC。对照组为310例无肝病患者，1：5配对，随机抽取同一家医院住院患者，无症状住院患者97例，均为初诊LC患者。通过标准化问卷对所有受试者的酒精摄入量进行量化。在肝硬变患者中，乙肝病毒感染与WCC的发生相关(优势比=6.8；95%可信区间=1.4-32.3)，而我们观察到随着饮酒量的增加，肝癌风险降低的趋势(终生戒酒者的优势比从1降至175g/天或更多饮酒者的0.2)。我们的结果表明，酒精摄入量不是肝癌的直接决定因素，但其作用是通过LC介导的。高酒精摄入量的肝硬变患者通常不会存活足够长的时间而患上肝细胞癌。
We carried out a hospital-based, case-control study to assess the association of both the Hepatitis B Virus (HBV) infection and the lifetime daily alcohol intake with the risk of developing hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). Cases were 62 consecutive inpatients of a Gastroenterology Division in whom a first diagnosis of HCC superimposed on LC was made. Two control groups were used: 310 patients without liver disease, matched 1:5 with cases and randomly selected from inpatients of the same hospital, and 97 consecutive asymptomatic inpatients in whom the first diagnosis of LC was made. Alcohol intake was quantified in all subjects by a standardized questionnaire. HBV infection was associated with WCC development in cirrhotics (odds ratio = 6.8; 95% confidence interval = 1.4 - 32.3), whereas we observed a trend towards a decreased HCC risk at increased alcohol intake values (odds ratio from 1 for lifetime abstainers to 0.2 for drinkers of 175 g/day or more). Our results suggest that alcohol intake is not a direct determinant of HCC, but its role is mediated by LC. Cirrhotics with high alcohol intake do not usually survive long enough to develop HCC.