Cognitive deficits of pure subcortical vascular dementia vs Alzheimer disease
Cognitive deficits of pure subcortical vascular dementia vs Alzheimer disease
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DOI：
10.1212/wnl.0b013e3182815485
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发表时间：
2013-02-01
期刊：
影响因子：
9.9
通讯作者：
Na, Duk L.
中科院分区：
文献类型：
--
作者：
Yoon, Cindy W.;Shin, Ji Soo;Na, Duk L.
目的：尽管许多神经心理学研究区分皮质下血管性痴呆（SVaD）从阿尔茨海默病（AD），以前的研究并没有消除混合阿尔茨海默病和血管病变的混杂效应。我们的目的是调查匹兹堡化合物B（PiB）阴性SVaD和PiB阳性AD患者之间的神经心理学差异。方法：我们招募了临床诊断为SVaD或AD并接受C-11-PiB-PET扫描的患者。所有SVaD患者均符合DSM-IV血管性痴呆标准，并有严重的白色高信号。AD的诊断是根据美国国立神经和交流障碍研究所和中风-阿尔茨海默病及相关疾病协会提出的可能AD的标准进行的。最终患者样本包括44/67（65.7%）PiB滞留检测阴性的SVaD患者[PiB（-）SVaD]和61/68（89.7%）PiB滞留检测阳性的AD患者[PiB（+）AD]。PiB（-）SVaD患者在言语和视觉记忆测试中的表现优于PiB（+）AD患者，包括首尔言语学习测试和Rey复杂图形测试的延迟回忆。结论：PiB（-）SVaD患者记忆力较PiB（+）AD患者好，但额叶功能较差。然而，由于截止阈值存在一些重叠，因此两组之间观察到的记忆/额叶功能差异无法区分所有个体数据。神经病学（R）2013;80：569-573
Objectives: Despite many neuropsychological studies to differentiate subcortical vascular dementia (SVaD) from Alzheimer disease (AD), previous studies did not eliminate confounding effects of mixed Alzheimer and vascular pathology. We aimed to investigate neuropsychological differences between patients with Pittsburgh compound B (PiB)-negative SVaD and those with PiB-positive AD.Methods: We recruited patients who were clinically diagnosed with SVaD or AD and underwent an C-11-PiB-PET scan. All patients with SVaD fulfilled DSM-IV criteria for vascular dementia and had severe white matter hyperintensities. The diagnosis of AD was made on the basis of criteria for probable AD proposed by the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association.Results: The final patient sample consisted of 44/67 (65.7%) patients with SVaD who tested negative for PiB retention [PiB(-) SVaD] and 61/68 (89.7%) patients with AD who tested positive for PiB retention [PiB(+) AD]. Patients with PiB(-) SVaD performed better than patients with PiB(+) AD on both verbal and visual memory tests including delayed recalls of the Seoul Verbal Learning Test and Rey Complex Figure Test. Patients with PiB(-) SVaD were worse than patients with PiB(+) AD on phonemic fluency of the Controlled Oral Word Association Test and Stroop color test.Conclusions: Patients with PiB(-) SVaD were better at memory but worse at frontal function than patients with PiB(+) AD. The differences in memory/frontal functions observed between the 2 groups, however, could not differentiate all individual data due to some overlap in the cutoff threshold. Neurology (R) 2013;80:569-573