Hypocholesterolemic effect of Lactobacillus GG in hypercholesterolemic rat
Hypocholesterolemic effect of Lactobacillus GG in hypercholesterolemic rat
复制标题
乳杆菌GG对高胆固醇血症大鼠的降胆固醇作用
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
A. Hosono
中科院分区：
文献类型：
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作者：
M. Tabuchi;Asako Tamura;Noriko Yamada;T. Ishida;M. Hosoda;A. Hosono
This study was conducted to clarify the mechanisms underlying the hypocholesterolemic effect of Lactobacillus GG (strain GG) on hypercholesterolemia in rats. Wistar rats were fed cholesterol-enriched diets supplemented with strain GG lyophilized cells for 3 weeks. The serum total cholesterol level was significantly lower in rats fed GG cells (GG) than in rats fed only cholesterol-enriched diets (Control), during the feeding period (p < 0.05). After the feeding period, the liver cholesterol accumulation was inhibited by the intake of GG cells. The serum bile acid level in the GG group was also lower than that in the control group. The fecal excretions of cholesterol and bile acid were significantly promoted in the GG group compared with the control group (p < 0.05). These results show that the hypocholesterolemic action of strain GG was due to the suppression of cholesterol absorption and bile acid reabsorption into the enterohepatic circulation.
