The comparative toxicity of volcanic ash and quartz. Effects on cells derived from the human lung.
The comparative toxicity of volcanic ash and quartz. Effects on cells derived from the human lung.
复制标题
火山灰和石英的毒性比较。
DOI：
10.1164/arrd.1984.130.5.778
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Altman,LC
中科院分区：
文献类型：
--
作者：
Martin,TR;Ayars,G;Butler,J;Altman,LC
为了评估火山灰和游离结晶二氧化硅对来自人肺的空气空间的细胞的影响，我们比较了这些矿物质对人肺泡巨噬细胞和A549细胞的影响，这些细胞来自人II型肺细胞。石英对肺泡巨噬细胞和A549细胞具有明显的细胞毒性，并刺激肺泡巨噬细胞释放中性粒细胞趋化活性。相比之下，火山灰对人肺泡巨噬细胞和A549细胞的毒性要小得多，并且不会刺激肺泡巨噬细胞释放中性粒细胞趋化活性。A549细胞的结果与从大鼠肺中回收的分离的II型肺细胞的结果相似。分泌型伊加、IgG和白蛋白（通常存在于肺的空气空间中）以剂量依赖性方式降低石英的细胞毒性。这些结果表明，在人类肺部石英，而不是火山灰，可能会导致直接损害细胞在肺泡空间，并导致招募吞噬细胞从血流到肺。
To evaluate the effects of volcanic ash and free crystalline silica on cells derived from the air space of the human lung, we compared the effects of these minerals on human alveolar macrophages and A549 cells, which are derived from human type II pneumocytes. The quartz was markedly cytotoxic to alveolar macrophages and A549 cells and stimulated the release of neutrophil chemotactic activity from alveolar macrophages. By contrast, volcanic ash was much less toxic to human alveolar macrophages and A549 cells and did not stimulate the release of neutrophil chemotactic activity from alveolar macrophages. The results with A549 cells were similar to findings with isolated type II pneumocytes recovered from rat lungs. Secretory IgA, IgG, and albumin, which are normally present in the air spaces of the lung, reduced the cytotoxicity of quartz in a dose-dependent manner. These results suggest that in the human lung quartz, but not volcanic ash, may cause direct damage to cells in the alveolar spaces and lead to the recruitment of phagocytes from the bloodstream to the lung.