Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis.
Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis.
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溃疡性结肠炎的抗结肠抗体和淋巴细胞抗体。
DOI：
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发表时间：
1982
影响因子：
4.6
通讯作者：
M. Tsuchiya
中科院分区：
文献类型：
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作者：
T. Hibi;S. Aiso;T. Yoshida;M. Watanabe;H. Asakura;S. Tsuru;M. Tsuchiya
用抗体依赖性细胞介导的细胞毒试验（ADCC）证实溃疡性结肠炎患者血清中存在抗结肠抗体。此外，通过荧光激活细胞分选仪（FACS）分析，在溃疡性结肠炎患者的血清中获得了高流行率的嗜淋巴细胞抗体。这种亲淋巴细胞抗体被大鼠结肠上皮细胞吸收。此外，溃疡性结肠炎的淋巴细胞对该抗体的结合能力较低，但在体外37 ℃孵育20小时后获得较高的结合能力。提示ADCC可能在溃疡性结肠炎的发病机制中起一定作用。
The presence of anti-colon antibody in the sera from patients with ulcerative colitis was demonstrated by antibody-dependent cell-mediated cytotoxicity (ADCC) assay. In addition, the high prevalence of lymphocytophilic antibody in the sera from patients with ulcerative colitis was obtained by fluorescence activated cell sorter (FACS) analysis. This lymphocytophilic antibody was absorbed by rat colon epithelial cells. Moreover the lymphocytes from ulcerative colitis showed lower binding capacity to this antibody, but acquired higher binding capacity after 20 hr incubation at 37 degrees C in vitro. These data suggest that ADCC may have some role in the pathogenesis of ulcerative colitis.