Intestinal ischemia reperfusion injury and multisystem organ failure.
Intestinal ischemia reperfusion injury and multisystem organ failure.
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DOI：
10.1053/j.sempedsurg.2003.09.003
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发表时间：
2004-02-01
影响因子：
1.7
通讯作者：
Eaton, Simon
中科院分区：
文献类型：
--
作者：
Pierro, Agostino;Eaton, Simon
肠缺血再灌注是婴幼儿、儿童和成人多种疾病的共同途径，可导致多器官功能障碍综合征和死亡。虽然有几项研究调查了心脏，脑和肝脏疾病的再灌注损伤，但关于肠缺血-再灌注及其多器官效应的研究有限。作者开发了大鼠肠缺血-再灌注模型，并证明在常温下肠再灌注导致肝脏能量衰竭。再灌注4小时内死亡率为100%。在整个缺血和再灌注过程中诱导的中度低温（32摄氏度至33摄氏度）可防止肝脏能量衰竭、肠损伤和肺中的中性粒细胞浸润。在这种肠缺血和再灌注模型中，中度低温可防止死亡。需要进一步的研究来确定治疗性低温是否是治疗缺血和再灌注引起的肠损伤的婴儿和儿童的有效干预措施。
Intestinal ischemia-reperfusion is a common pathway for many diseases in infants, children, and adults, and this may lead to multiple organ dysfunction syndrome and death. While several studies have investigated reperfusion injury in cardiac, cerebral, and hepatic disease, limited work has been published on intestinal ischemia-reperfusion and its multiorgan effects. The authors have developed models of intestinal ischemia-reperfusion in rats and have demonstrated that intestinal reperfusion causes liver energy failure at normothermia. This is followed by 100% mortality within 4 hours of reperfusion. Moderate hypothermia (32 degrees C to 33 degrees C) induced throughout ischemia and reperfusion prevents liver energy failure, intestinal damage, and neutrophil infiltration in the lungs. Moderate hypothermia in this model of intestinal ischemia and reperfusion prevents mortality. Further studies are needed to establish whether therapeutic hypothermia is a useful intervention in the treatment of infants and children with intestinal injuries caused by ischemia and reperfusion.