Acute effects of nicotine administration during prospective memory, an event related fMRI study.
Acute effects of nicotine administration during prospective memory, an event related fMRI study.
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尼古丁给药对前瞻性记忆的急性影响，一项事件相关的功能磁共振成像研究。
DOI：
10.1016/j.neuropsychologia.2011.04.009
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发表时间：
2011
期刊：
影响因子：
2.6
通讯作者：
Rusted J
中科院分区：
文献类型：
--
作者：
Rusted J
我们以前证明，刺激神经元烟碱乙酰胆碱受体调节前瞻性记忆（PM），记忆和实现先前意图的能力。在这里，我们使用功能磁共振成像探索急性烟碱（1毫克）调制PM期间的神经元相关性，采用双盲，效价匹配的安慰剂对照设计，和一个单独的事件相关分析。八名健康成人完成了两次（1周洗脱期）一个简单的注意力任务，包含不频繁的PM试验。PM激活双侧顶叶、前额叶（BA 10）和前扣带回，使膝扣带回和内侧前额叶失活。此外，急性尼古丁给药降低了在很大程度上重叠的右顶叶区域内的活动。这些数据验证了一个纯粹的事件相关的方法来探索PM，并建议procholinergic调制PM顶叶，而不是BA 10/额叶区域。
We previously demonstrated that stimulating neuronal nicotinic acetylcholine receptors modulates prospective memory (PM), the ability to remember and implement a prior intention. Here we used fMRI to explore the neuronal correlates of acute nicotinic (1mg) modulation during PM, employing a double blind, valence-matched placebo-controlled design, and a solely event-related analysis. Eight healthy adults completed on two occasions (1 week washout) a simple attentional task containing infrequent PM trials. PM activated bilateral parietal, prefrontal (BA10) and anterior cingulate, and deactivated genual cingulate and medial prefrontal regions. Further, acute nicotine administration decreased activity within a largely overlapping right parietal region. This data validates a purely event-related approach to exploring PM, and suggests procholinergic modulation of PM by parietal rather than BA10/frontal regions.