Interval cancers in a randomized controlled trial of screening for colorectal cancer using a faecal occult blood test
Interval cancers in a randomized controlled trial of screening for colorectal cancer using a faecal occult blood test
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DOI：
10.1093/ije/28.3.386
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发表时间：
1999-06-01
影响因子：
7.7
通讯作者：
Rodrigues, VC
中科院分区：
文献类型：
--
作者：
Moss, SM;Hardcastle, JD;Rodrigues, VC
背景在英国诺丁汉大便潜血筛查结直肠癌的随机对照试验的背景下，研究了非水化血隐血II的敏感性。方法采用传统和比例发生率法分别计算男女、两个年龄组、首次筛查和重复筛查以及大肠内三个部位的敏感性。结果传统估计法的敏感性为59%，而比例发生率法得到的相应数字为54%。两种方法的估计结果之间的差异在进入试验时大于或等于65岁的受试者和远端结肠癌中最大。结论研究结果表明，在大于或等于65岁的受试者中，生长缓慢的肿瘤比例可能更高，发生在远端结肠的癌症可能比乙状结肠近端的癌症有更长的平均停留时间。
Background The sensitivity of unhydrated Haemoccult II has been examined in the context of a randomized controlled trial of faecal occult blood screening for colorectal cancer in Nottingham, UK.Method Both traditional and proportional incidence methods were used to calculate sensitivity separately for both sexes, for two age groups at entry to the trial, for first screen and repeat screens and for three subsites within the large bowel.Results The traditional method of estimation yielded a sensitivity of 59% whereas the corresponding figure obtained using the proportional incidence method was 54%. The difference between the estimates using the two methods was greatest in subjects aged greater than or equal to 65 at entry to the trial and in cancers of the distal colon.Conclusions The results suggest that there may be a higher proportion of slower growing tumours in subjects aged greater than or equal to 65 and that cancers occurring in the distal colon may have a longer mean sojourn time than cancers proximal to the sigmoid colon.