Association between serum cotinine level and prevalence of non-alcoholic fatty liver disease: a cross-sectional study from the Third National Health and Nutrition Examination Survey.
Association between serum cotinine level and prevalence of non-alcoholic fatty liver disease: a cross-sectional study from the Third National Health and Nutrition Examination Survey.
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DOI：
10.1136/jim-2016-000213
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发表时间：
2017-01
期刊：
影响因子：
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通讯作者：
Liangpunsakul S
中科院分区：
文献类型：
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作者：
Shen H;Peng JL;Tayarachakul S;Liangpunsakul S
关于吸烟对非酒精性脂肪性肝病(NAFLD)的影响的数据一直存在争议。这项研究的目的是调查血清可替宁水平(一种烟草生物标记物)与美国普通人群中NAFLD患病率之间是否存在关联。我们对第三次全国健康和营养检查调查(NHANES III)的数据进行了横断面分析。我们包括11,003名年龄在20-74岁之间的成年人，他们接受了超声检查。在这些人中，4036人被确认为NAFLD，6967人被确认为对照组。NAFLD患者当前吸烟者的百分比显著低于对照组(21.5%vs26.0%，p<；0.01)。在调整了潜在的混杂因素后，现在或以前吸烟者与NAFLD之间没有关联。此外，没有观察到血清可替宁水平与NAFLD之间的关联。各四分位水平的血清可替宁水平与NAFLD之间没有相关性，与吸烟状态无关。在这项以美国人群为基础的大型研究中，我们没有发现NAFLD与自我报告的吸烟状况或测量的血清可替宁水平之间的关联。
The data on the effect of smoking on non-alcoholic fatty liver disease (NAFLD) has been controversial. The aim of this study was to investigate if an association exists between serum cotinine level (a tobacco biomarker) and NAFLD prevalence in the general US population. We conducted a crosssectional analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III). We included 11,003 adults aged 20–74 years who underwent ultrasonography. Of those, 4036 were identified as having NAFLD and 6967 were recognized as controls. The percentage of current smokers was significantly lower in subjects with NAFLD compared with those in controls (21.5% vs 26.0%, p<0.01). After adjustment for potential confounders, there was no association between current or former smokers with NAFLD. Additionally, no associations were observed between the levels of serum cotinine and NAFLD. No association between serum cotinine levels at each quartile level and NAFLD was observed regardless of smoking status. In this large US population-based study, we did not find an association between NAFLD and self-reported smoking status or measured serum cotinine level.