VASCULAR ENDOTHELIAL GROWTH FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC RETINOPATHY AND OTHER RETINAL DISORDERS
VASCULAR ENDOTHELIAL GROWTH FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC RETINOPATHY AND OTHER RETINAL DISORDERS
复制标题
作者：
J. L.
背景视网膜缺血诱导眼内新生血管形成，这通常导致青光眼、玻璃体出血和视网膜脱离，推测是通过刺激血管生成分子的释放。血管内皮生长因子（VEGF）是一种内皮细胞特异性的血管生成因子，其产生由缺氧增加。结论.我们的数据表明，VEGF在介导缺血性视网膜疾病（如糖尿病视网膜病变和视网膜静脉阻塞）患者的活跃眼内新生血管形成中起重要作用。
Background. Retinal ischemia induces intraocular neovascularization, which often leads to glaucoma, vitreous hemorrhage, and retinal detachment, presumably by stimulating the release of angiogenic molecules. Vascular endothelial growth factor (VEGF) is an endothelial-cell-specific angiogenic factor whose production is increased by hypoxia. Conclusions. Our data suggest that VEGF plays a major part in mediating active intraocular neovascularization in patients with ischemic retinal diseases, such as diabetic retinopathy and retinal-vein occlusion.