LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21
LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21
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DOI：
10.1126/science.2270482
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发表时间：
1990-12-21
期刊：
影响因子：
56.9
通讯作者：
KING, MC
中科院分区：
文献类型：
--
作者：
HALL, JM;LEE, MK;KING, MC
人类乳腺癌通常是由乳腺体细胞的遗传改变引起的，但偶尔，对疾病的易感性是遗传的。绘制遗传性乳腺癌的基因图谱还可以识别对一般人群中乳腺癌发展至关重要的早期病变。染色体17q21似乎是早发性乳腺癌家族遗传易感性基因的所在地。遗传分析得出的lod得分（对数似然比连锁）为5.98的连锁乳腺癌易感性D17S74的早发性家庭和负lod得分的家庭与晚发性疾病。在该地区的4个位点的多点分析的基础上，有利于家庭之间的连锁异质性的似然比在2000：1和大于106：1。
Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Mapping the genes responsible for inherited breast cancer may also allow the identification of early lesions that are critical for the development of breast cancer in the general population. Chromosome 17q21 appears to be the locale of a gene for inherited susceptibility to breast cancer in families with early-onset disease. Genetic analysis yields a lod score (logarithm of the likelihood ratio for linkage) of 5.98 for linkage of breast cancer susceptibility to D17S74 in early-onset families and negative lod scores in families with late-onset disease. Likelihood ratios in favor of linkage heterogeneity among families ranged between 2000:1 and greater than 106:1 on the basis of multipoint analysis of four loci in the region.