Blonanserin suppresses impulsive action in rats
Blonanserin suppresses impulsive action in rats
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DOI：
10.1016/j.jphs.2019.09.013
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发表时间：
2019-11-01
影响因子：
3.5
通讯作者：
Yoshioka, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Nishitani, Naoya;Sasamori, Hitomi;Yoshioka, Mitsuhiro
高度冲动会增加犯罪行为、吸毒和自杀的风险。我们按照最近提出的识别潜在抗冲动药物的策略选择了两种药物，并通过使用三项选择的串行反应时间任务检查了对大鼠冲动行为的影响。我们发现，服用布南色林（一种非典型抗精神病药）可以以 U 形方式减少冲动行为。 1-(2-吡啶基)-哌嗪是丁螺环酮或坦度螺酮的活性代谢物，虽然会损害运动功能，但也会稍微减少冲动行为。这些结果证实了我们策略的有效性，但需要对其进行改进以开发抗冲动药物。 (C) 2019 年作者。由 Elsevier B.V. 制作和主持
High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs. (C) 2019 The Authors. Production and hosting by Elsevier B.V.