Human obesity as a heritable disorder of the central control of energy balance
Human obesity as a heritable disorder of the central control of energy balance
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DOI：
10.1038/ijo.2008.239
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发表时间：
2008-12-01
影响因子：
4.9
通讯作者：
Farooqi, I. S.
中科院分区：
文献类型：
--
作者：
O'Rahilly, S.;Farooqi, I. S.
本着庆祝彭宁顿生物医学研究中心成立20周年的精神，我们抓住机会，对大量证据进行了一次高度个人化的、根本不全面的“短暂停留之旅”，我们认为这些证据支持以下结论：（1）人体脂肪储存受到生物控制过程的调节，就像它们在低等动物中一样;（2）遗传因素对这种控制过程在人类中发挥作用的效率有重大影响;（3）这些遗传和生物影响的确切性质以及它们如何与环境因素相互作用正开始被理解;（4）迄今为止发现的大多数基因对饥饿、饱腹和食物摄入有主要影响;（5）虽然人们对基因可以影响人类行为（如食物的习惯性摄入）的观点存在可以理解的抵制，但这些发现的影响基本上是良性的。事实上，我们希望它们最终能改善对病人的治疗，此外，还能帮助灌输对肥胖者更开明的态度，减少他们受到社会和经济歧视的经历。
In the spirit of celebration associated with the 20th anniversary of the Pennington Biomedical Research Center, we have seized the opportunity of taking a highly personal and not at all comprehensive 'whistle-stop tour' of a large body of evidence that, we feel, supports the following conclusions: (1) that body fat stores are regulated by biological control processes in humans as they are in lower animals; (2) that there are major inherited influences on the efficiency whereby such control processes operate in humans; (3) that the precise nature of those genetic and biological influences and how they interact with environmental factors are beginning to be understood; (4) that most of the genes discovered thus far have their principal impact on hunger, satiety and food intake; (5) that while there is understandable resistance to the notion that genes can influence a human behavior such as the habitual ingestion of food, the implications of these discoveries are essentially benign. Indeed, we hope that they may eventually lead to improved treatment for patients and, in addition, help to inculcate a more enlightened attitude to the obese with a reduction in their experience of social and economic discrimination.