Blunted Metabolic Responses to Cold and Insulin Stimulation in Brown Adipose Tissue of Obese Humans
Blunted Metabolic Responses to Cold and Insulin Stimulation in Brown Adipose Tissue of Obese Humans
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DOI：
10.1002/oby.20456
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发表时间：
2013-11-01
期刊：
影响因子：
6.9
通讯作者：
Virtanen, Kirsi A.
中科院分区：
文献类型：
--
作者：
Orava, Janne;Nuutila, Pirjo;Virtanen, Kirsi A.
目的：非活性棕色脂肪组织（BAT）可能导致体重增加。这项研究旨在测量肥胖人群BAT的代谢，并将其与瘦人群进行比较。体重减轻对BAT的影响和可检测的BAT与各种代谢特征的关联也assessed.Design和方法：使用正电子发射断层扫描（PET），冷和胰岛素刺激的葡萄糖摄取和血流量在BAT的肥胖和瘦的人进行了量化。此外，冷诱导的葡萄糖摄取测量肥胖受试者之前和之后的5个月的常规weight loss.Results：BAT葡萄糖摄取率的平均反应冷和胰岛素刺激的两倍大瘦肥胖受试者。在寒冷条件下，肥胖受试者的BAT血流量也较低。体重减轻后冷诱导BAT葡萄糖摄取率的增加没有统计学意义。受试者与冷激活的可检测的BAT瘦，并有较高的全身胰岛素敏感性比BAT阴性subjects，不论年龄和gender.Conclusions：冷和胰岛素对BAT活性的影响是严重钝化肥胖，和存在的可检测的BAT可能有助于代谢健康状态。
Objective: Inactive brown adipose tissue (BAT) may predispose to weight gain. This study was designed to measure metabolism in the BAT of obese humans, and to compare it to that in lean subjects. The impact of weight loss on BAT and the association of detectable BAT with various metabolic characteristics were also assessed.Design and Methods: Using positron emission tomography (PET), cold-and insulin-stimulated glucose uptake and blood flow in the BAT of obese and lean humans were quantified. Further, cold-induced glucose uptake was measured in obese subjects before and after a 5-month conventional weight loss.Results: Mean responses in BAT glucose uptake rate to both cold and insulin stimulation were twice as large in lean as in obese subjects. Blood flow in BAT was also lower in obese subjects under cold conditions. The increase in cold-induced BAT glucose uptake rate after weight loss was not statistically significant. Subjects with cold-activated detectable BAT were leaner and had higher whole-body insulin sensitivity than BAT-negative subjects, irrespective of age and gender.Conclusions: The effects of cold and insulin on BAT activity are severely blunted in obesity, and the presence of detectable BAT may contribute to a metabolically healthy status.