Meta-analysis of Telomere Length in Alzheimer's Disease
Meta-analysis of Telomere Length in Alzheimer's Disease
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DOI：
10.1093/gerona/glw053
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发表时间：
2016-08-01
影响因子：
5.1
通讯作者：
Perry, George
中科院分区：
文献类型：
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作者：
Forero, Diego A.;Gonzalez-Giraldo, Yeimy;Perry, George
阿尔茨海默病（Alzheimer's disease，AD）是一种常见的严重的神经退行性疾病。人类端粒是维持基因组稳定性的基础，在细胞衰老和生物体衰老中起着重要作用。端粒长度的调控是环境和遗传因素复杂相互作用的结果。TL的改变越来越多地被研究作为AD的一个可能的危险因素，并发表的研究TL在AD显示不一致的结果，突出需要一个荟萃分析。在目前的研究中，我们进行了荟萃分析已发表的研究TL在AD患者和健康对照。使用PubMed、Web of Science和Google Scholar数据库（从开始到2015年9月）识别报告AD患者TL的相关文章，从中检索数据，如样本量、实验方法和病例和对照的平均TL。荟萃分析采用随机效应模型，包括13项主要研究，860例AD患者和2,022例对照者的TL存在显著差异，标准化平均差异为-0.984（置信区间：-1.433至-0.535; p值：
Alzheimer's disease (AD) is a common and severe neurodegenerative disorder. Human telomeres are fundamental for the maintenance of genomic stability and play prominent roles in both cellular senescence and organismal aging. Regulation of telomere length (TL) is the result of the complex interplay between environmental and genetic factors. Alterations in TL are increasingly being studied as a possible risk factor for AD, and published studies on TL in AD show discrepant results, highlighting the need for a meta-analysis.In the current study, we carried out a meta-analysis of published studies of TL in AD patients and healthy controls. PubMed, Web of Science and Google Scholar databases (from inception to September 2015) were used to identify relevant articles reporting TL in humans with AD, from which we retrieved data such as sample size, experimental methods, and mean TL for cases and controls. A random-effects model was used for meta-analytical procedures.The meta-analysis included 13 primary studies and demonstrated a significant difference in TL between 860 AD patients and 2,022 controls, with a standardized mean difference of -0.984 (confidence interval: -1.433 to -0.535; p value: