Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells.
Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells.
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DOI：
10.4049/jimmunol.162.9.5094
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发表时间：
1999-05
影响因子：
4.4
通讯作者：
M. Emoto;H. Mittrücker;Rudolf Schmits;Tak W. Mak;Stefan H. E. Kaufmann
中科院分区：
文献类型：
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作者：
M. Emoto;H. Mittrücker;Rudolf Schmits;Tak W. Mak;Stefan H. E. Kaufmann
与外周淋巴器官相比，肝脏中CD4+NKT细胞占T细胞的高比例。我们想知道粘附分子是否在肝脏中CD4+NKT细胞的积累中起作用。肝脏CD4+NKT细胞表达ICAM-1和高水平LFA-1。lfa -1缺失小鼠肝脏中CD4+NKT细胞数量明显减少。这种减少仅限于肝脏，在分析的其他器官中没有发现减少。相比之下，icam -1缺陷小鼠的肝脏CD4+NKT细胞数量仅轻微减少。在LFA-1缺陷小鼠和野生型小鼠的互反辐射胸腺细胞重建系统中，肝脏中CD4+NKT细胞以外的肝细胞上表达LFA-1是CD4+NKT细胞在肝脏中积累所必需的。这些结果表明LFA-1在肝脏中CD4+NKT细胞的积累中起着至关重要的作用。
In contrast to peripheral lymphoid organs, a high percentage of T cells in the liver are CD4+NKT cells. We asked whether adhesion molecules play any role in the accumulation of CD4+NKT cells in the liver. Liver CD4+NKT cells expressed ICAM-1 and high levels of LFA-1. In the livers of LFA-1-deficient mice, the number of CD4+NKT cells was markedly decreased. This reduction was restricted to the liver, and no reduction was found in the other organs analyzed. In contrast, the number of liver CD4+NKT cells in ICAM-1-deficient mice was only marginally reduced. In a reciprocal radiation thymocyte reconstitution system with LFA-1-deficient and wild-type mice, LFA-1 expressed on liver cells other than CD4+NKT cells was required for an accumulation of CD4+NKT cells in the liver. These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver.