The effects of naloxone, diprenorphine, and diazepam on responding suppressed by pre-shock and pre-food stimuli.
The effects of naloxone, diprenorphine, and diazepam on responding suppressed by pre-shock and pre-food stimuli.
复制标题
纳洛酮、地丙诺啡和地西泮对电击前和食物前刺激抑制的反应的影响。
DOI：
10.1016/0024-3205(83)90141-8
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发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
Holtzman,SG
中科院分区：
文献类型：
--
作者：
White,JM;Holtzman,SG
按可变间隔1min进食加强大鼠的杠杆按压。在一组人中，偶尔照亮提示灯30秒后，会有短暂的电击；在这些时间段，反应被抑制。纳洛酮(0.01-10 mg/kg)不改变休克前刺激时反应被抑制的程度。异丙诺啡(0.1-10 mg/kg)轻微减弱抑制，安定(1.0-3.0 mg/kg)使刺激时的反应增强至正常水平。这些结果证实，阿片类拮抗剂并不总是增强休克对行为的影响。在第二组中，偶尔照亮提示灯20秒后，就会送上免费的食物颗粒。在食品之前的刺激期间，反应也受到抑制。纳洛酮和丙泊诺啡在刺激过程中对应答率均无影响。与早期使用苯二氮卓类药物的研究结果相反，安定(1.0-3.0 mg/kg)在食物刺激前产生了显著的反应抑制减弱。
The lever-pressing of rats was reinforced with food according to a variable-interval 1-min schedule. In one group, occasional illumination of cue lights for 30-sec periods was followed by a brief electric shock; responding was suppressed during these periods. Naloxone (0.01–10 mg/kg) did not change the degree to which responding was suppressed during the pre-shock stimulus. Diprenorphine (0.1–10 mg/kg) slightly attenuated suppression, and diazepam (1.0–3.0 mg/kg) increased responding during the stimulus to normal levels. These results confirm that opiate antagonists do not always enhance the effects of shock on behavior. In a second group, occasional illumination of the cue lights for 20-sec periods was followed by delivery of free food pellets. Responding was also suppressed during the pre-food stimulus. Neither naloxone nor diprenorphine had any effect on response rate during this stimulus. In contrast to the results of earlier studies using benzodiazepines, diazepam (1.0–3.0 mg/kg) produced a marked attenuation of response suppression during the pre-food stimulus.