European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo
European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo
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DOI：
10.1111/jdv.14570
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发表时间：
2018-07-01
影响因子：
9.2
通讯作者：
Staender, S.
中科院分区：
文献类型：
--
作者：
Pereira, M. P.;Steinke, S.;Staender, S.
背景皮肤科使用了几十年的术语“黑色素瘤”，没有明确的定义，目前使用的术语“黑色素瘤”是不一致和混乱的。特别是，瘙痒相关的瘙痒症仍然是未探索的流行病学，临床资料，自然过程，根本原因，可用的治疗和经济负担，虽然繁重和难以treat. ObjectiveTo解决这些问题，多中心的欧洲瘙痒症项目（EPP）的目的是增加对慢性瘙痒症（CPG）的认识。第一步，EADV瘙痒症工作组（TFP）的欧洲专家旨在就CPG的定义、分类和术语达成共识。此外，程序的横截面EPP进行了讨论和agreedupon.Methods讨论和调查的TFP成员之间作为共识会议的基础。采用德尔菲法，将共识定义为与会成员一致性≥ 75%。专家们一致认为，CPG应用作一系列临床表现（如丘疹、结节、斑块或脐型）的总称。CPG被认为是一种独特的疾病，其定义为存在6周的慢性瘙痒、反复抓挠病史和/或体征以及多发性局部/全身性色素性皮肤病变（白色或粉红色丘疹、结节和/或斑块）。CPG的发生是由于神经元致敏瘙痒和发展的瘙痒-抓挠cycle.Conclusion这个新的定义和术语的CPG应在皮肤科实施，以协调沟通的临床常规，临床试验和科学文献。急性/亚急性形式的类风湿性关节炎是独立的实体，需要与CPG区分开来，并将在下一步进行讨论。在不久的将来，横断面EPP将提供有关CPG各个方面的相关临床数据，从而为CGP的科学研究提供新的方向。
Background The term prurigo has been used for many decades in dermatology without clear definition, and currently used terminology of prurigo is inconsistent and confusing. Especially, itch-related prurigo remains unexplored regarding the epidemiology, clinical profile, natural course, underlying causes, available treatments and economic burden, although burdensome and difficult to treat.Objective To address these issues, the multicentre European Prurigo Project (EPP) was designed to increase knowledge on chronic prurigo (CPG). In the first step, European experts of the EADV Task Force Pruritus (TFP) aimed to achieve a consensus on the definition, classification and terminology of CPG. Additionally, procedures of the cross-sectional EPP were discussed and agreed upon.Methods Discussions and surveys between members of the TFP served as basis for a consensus conference. Using the Delphi method, consensus was defined as an agreement >= 75% among the present members.Results Twenty-four members of the TFP participated in the consensus conference. Experts consented that CPG should be used as an umbrella term for the range of clinical manifestations (e.g. papular, nodular, plaque or umbilicated types). CPG is considered a distinct disease defined by the presence of chronic pruritus for 6 weeks, history and/or signs of repeated scratching and multiple localized/generalized pruriginous skin lesions (whitish or pink papules, nodules and/or plaques). CPG occurs due to a neuronal sensitization to itch and the development of an itch-scratch cycle.Conclusion This new definition and terminology of CPG should be implemented in dermatology to harmonize communication in the clinical routine, clinical trials and scientific literature. Acute/subacute forms of prurigo are separated entities, which need to be differentiated from CPG and will be discussed in a next step. In the near future, the cross-sectional EPP will provide relevant clinical data on various aspects of CPG leading to new directions in the scientific investigation of CGP.