Further evaluation of the synthetic peptide vaccine S3Pvac against Taenia solium cysticercosis in pigs in an endemic town of Mexico
Further evaluation of the synthetic peptide vaccine S3Pvac against Taenia solium cysticercosis in pigs in an endemic town of Mexico
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DOI：
10.1017/s0031182006001132
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发表时间：
2007-01-01
期刊：
影响因子：
2.4
通讯作者：
Larralde, C.
中科院分区：
文献类型：
--
作者：
Sciutto, E.;Morales, J.;Larralde, C.
猪带绦虫囊尾蚴病是一种寄生虫病，在许多发展中国家经常影响人类健康和养猪业。以前已经开发了一种抗猪囊尾蚴病的合成肽疫苗（命名为S3Pvac），作为阻断传播的辅助手段，并已证明是有效的。本研究的结果支持疫苗在地方性流行现场条件下的有效性。然而，考虑到疫苗接种试验的时间范围，在使用哨兵猪接种疫苗前后，未检测到当地传播水平的变化。因此，这项调查表明，单一的疫苗接种作为唯一的手段，中断猪带绦虫在流行地区传播的有限用途。
Taenia solium cysticercosis is a parasitic disease frequently affecting human health and the pig industry in many developing countries. A synthetic peptide vaccine (designated S3Pvac) against porcine cysticercosis has been developed previously as an aid to interrupt transmission and has been shown to be effective. The results of the present study support the effectiveness of the vaccine under endemic field conditions. However, given the time-frame of the vaccination trial, no changes in the local levels of transmission were detectable before and after vaccination using sentinel pigs. Thus, this investigation shows the limited usefulness of single vaccination as the sole means of interrupting Taenia solium transmission in an endemic region.