The Significance of Tumor Necrosis Factor Receptor Type II in CD8(+) Regulatory T Cells and CD8(+) Effector T Cells.
The Significance of Tumor Necrosis Factor Receptor Type II in CD8(+) Regulatory T Cells and CD8(+) Effector T Cells.
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CD8调节性T细胞和CD8效应T细胞中II型肿瘤坏死因子受体的意义
DOI：
10.3389/fimmu.2018.00583
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发表时间：
2018
影响因子：
7.3
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Ye LL;Wei XS;Zhang M;Niu YR;Zhou Q
肿瘤坏死因子（TNF）是一种多效性细胞因子，具有促炎和抗炎作用。TNF的生物学功能由两种受体介导，TNF受体I型（TNFR 1）和TNF受体II型（TNFR 2）。TNFR 1在几乎所有细胞类型上普遍表达，并已被广泛研究，而TNFR 2主要限于免疫细胞和一些肿瘤细胞，其作用远未阐明。研究表明，TNFR2介导TNF对CD4+Foxp3+调节性T细胞（TCLs）和CD8+Foxp3+ TCLs的刺激活性，并参与TCLs的表型稳定性、增殖、活化和抑制活性。TNFR2还可以在CD8+效应T细胞（Teff）上表达，其在早期免疫应答期间向CD8+ Teff递送活化信号和细胞毒性能力，以及细胞凋亡信号以终止免疫应答。TNFR2诱导的TNF受体相关因子2（TRAF2）降解的消除可能在这些过程中发挥重要作用。因此，由于TNFR 2的分布及其多效性，TNFR 2似乎对保持Teff和Teff之间的平衡至关重要，并且可能是肿瘤和自身免疫性疾病的有效治疗靶点。在这篇综述中，我们总结了TNFR2在CD8+Foxp3+ T细胞和CD8+ T细胞上表达的生物学功能，并强调了TNF如何使用TNFR2来协调最终导致有效的CD8+ T细胞介导的免疫应答的复杂事件。
Tumor necrosis factor (TNF) is a pleiotropic cytokine that has both pro-inflammatory and anti-inflammatory functions. The biological functions of TNF are mediated by two receptors, TNF receptor type I (TNFR1) and TNF receptor type II (TNFR2). TNFR1 is expressed universally on almost all cell types and has been extensively studied, whereas TNFR2 is mainly restricted to immune cells and some tumor cells and its role is far from clarified. Studies have shown that TNFR2 mediates the stimulatory activity of TNF on CD4+Foxp3+ regulatory T cells (Tregs) and CD8+Foxp3+ Tregs, and is involved in the phenotypic stability, proliferation, activation, and suppressive activity of Tregs. TNFR2 can also be expressed on CD8+ effector T cells (Teffs), which delivers an activation signal and cytotoxic ability to CD8+ Teffs during the early immune response, as well as an apoptosis signal to terminate the immune response. TNFR2-induced abolition of TNF receptor-associated factor 2 (TRAF2) degradation may play an important role in these processes. Consequently, due to the distribution of TNFR2 and its pleiotropic effects, TNFR2 appears to be critical to keeping the balance between Tregs and Teffs, and may be an efficient therapeutic target for tumor and autoimmune diseases. In this review, we summarize the biological functions of TNFR2 expressed on CD8+Foxp3+ Tregs and CD8+ Teffs, and highlight how TNF uses TNFR2 to coordinate the complex events that ultimately lead to efficient CD8+ T cell-mediated immune responses.
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影响因子：
--
作者：
Cabal-Hierro L;Artime N;Iglesias J;Prado MA;Ugarte-Gil L;Casado P;Fernández-García B;Darnay BG;Lazo PS
通讯作者：
Lazo PS
DOI：
10.1159/000289201
发表时间：
2010
期刊：
Current directions in autoimmunity
影响因子：
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作者：
Chen X;Oppenheim JJ
通讯作者：
Oppenheim JJ
DOI：
10.1084/jem.20151563
发表时间：
2016-08-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Beilhack A
影响因子：
5.4
作者：
Chen, Xin;Subleski, Jeffrey J.;Hamano, Ryoko;Howard, O. M. Zack;Wiltrout, Robert H.;Oppenheim, Joost J.
通讯作者：
Oppenheim, Joost J.
DOI：
10.1084/jem.20070784
发表时间：
2007-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Almeida JR;Price DA;Papagno L;Arkoub ZA;Sauce D;Bornstein E;Asher TE;Samri A;Schnuriger A;Theodorou I;Costagliola D;Rouzioux C;Agut H;Marcelin AG;Douek D;Autran B;Appay V
通讯作者：
Appay V