Testosterone suppression of CRH-stimulated cortisol in men
Testosterone suppression of CRH-stimulated cortisol in men
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DOI：
10.1038/sj.npp.1300742
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发表时间：
2005-10-01
影响因子：
7.6
通讯作者：
Nieman, L
中科院分区：
文献类型：
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作者：
Rubinow, DR;Roca, CA;Nieman, L
尽管观察到下丘脑-垂体-肾上腺（HPA）轴活动存在年龄依赖性性两性异形，但雄激素在男性HPA轴活动调节中的作用尚未得到研究。我们通过在10名男性（年龄18 - 45岁）中进行CRH刺激试验，在醋酸亮丙瑞林性腺抑制期间和亮丙瑞林加用睾酮期间评估了这一作用。CRH刺激的皮质醇水平以及皮质醇峰值和最大皮质醇波动显著降低（p
Despite observations of age-dependent sexual dimorphisms in hypothalamic - pituitary - adrenal (HPA) axis activity, the role of androgens in the regulation of HPA axis activity in men has not been examined. We assessed this role by performing CRH stimulation tests in 10 men ( ages 18 - 45 years) during gonadal suppression with leuprolide acetate and during testosterone addition to leuprolide. CRH-stimulated cortisol levels as well as peak cortisol and greatest cortisol excursion were significantly lower (p