[Roles of cytokines in the pathogenesis of heart failure].
[Roles of cytokines in the pathogenesis of heart failure].
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发表时间：
2003-05
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通讯作者：
A. Matsumori
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作者：
A. Matsumori
细胞因子越来越被认为是心力衰竭发病机制和病理生理学的重要因素。据报道，心力衰竭患者循环细胞因子水平升高，并且多种细胞因子已被证明在体外和体内抑制心肌收缩力。我们最近的研究表明，各种心力衰竭药物调节细胞因子的产生，其中一些药物抑制NF-κ B B的活化。细胞因子基因治疗抑制病毒IL-10和IL-1受体拮抗剂的炎症反应，已被证明是有效的心力衰竭动物模型。肥大细胞在病毒性心肌炎心力衰竭的发病机制中起重要作用，并参与心肌代偿性肥大向心力衰竭的转变。
Cytokines are being increasingly recognized as important factors in the pathogenesis and pathophysiology of heart failure. Elevated levels of circulating cytokines have been reported in patients with heart failure, and various cytokines have been shown to depress myocardial contractility in vitro and in vivo. Our recent study showed that the various drugs for heart failure modulated the production of cytokines, and some of these drugs inhibited activation of NF-kappa B. Cytokine gene therapy which inhibits inflammatory response by viral IL-10 and IL-1 receptor antagonist has been shown to be effective in the animal models of heart failure. Mast cells have been shown to play important role in the pathogenesis of heart failure due to viral myocarditis, and transition from compensated hypertrophy to heart failure.