Incomplete hippocampal inversion in schizophrenia: prevalence, severity, and impact on hippocampal structure.
Incomplete hippocampal inversion in schizophrenia: prevalence, severity, and impact on hippocampal structure.
复制标题
精神分裂症的不完全海马倒置：患病率、严重程度以及对海马结构的影响。
DOI：
10.1038/s41380-020-01010-z
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发表时间：
2021
影响因子：
11
通讯作者：
Heckers,Stephan
中科院分区：
文献类型：
--
作者：
Roeske,MaxwellJ;McHugo,Maureen;Vandekar,Simon;Blackford,JenniferUrbano;Woodward,NeilD;Heckers,Stephan
不完全性海马体反转(IHI)是人脑的一种解剖变异，由大脑发育停滞引起，尤其在左半球普遍存在。我们假设IHI在精神分裂症中更为常见，并导致众所周知的海马区结构差异。我们对199例精神分裂症患者和16 1例健康对照进行了3 T磁共振检查，以确定IHI的患病率及其与海马体体积和对称性的关系。与健康对照组参与者相比，IHI更为普遍(左半球：15%的健康对照组参与者，27%的精神分裂症患者；右半球：4%的健康对照组参与者，10%的精神分裂症患者)，精神分裂症患者的病情更严重。严重的IHI病例与较高的自动分割失败率相关。IHI导致精神分裂症患者海马区体积变小，R>；L体积不对称性增加。IHI患病率和严重性的增加支持了精神分裂症的神经发育模式。这种发育变异的影响值得在精神分裂症的海马体研究中进一步探索。
Incomplete hippocampal inversion (IHI) is an anatomical variant of the human brain resulting from an arrest in brain development, especially prevalent in the left hemisphere. We hypothesized that IHI is more common in schizophrenia and contributes to the well-known hippocampal structural differences. We studied 199 schizophrenia patients and 161 healthy control participants with 3 T MRI to establish IHI prevalence and the relationship of IHI with hippocampal volume and asymmetry. IHI was more prevalent (left hemisphere: 15% of healthy control participants, 27% of schizophrenia patients; right hemisphere: 4% of healthy control participants, 10% of schizophrenia patients) and more severe in schizophrenia patients compared to healthy control participants. Severe IHI cases were associated with a higher rate of automated segmentation failure. IHI contributed to smaller hippocampal volume and increasedR>Lvolume asymmetry in schizophrenia. The increased prevalence and severity of IHI supports the neurodevelopmental model of schizophrenia. The impact of this developmental variant deserves further exploration in studies of the hippocampus in schizophrenia.