Effect of cysteine on the survival of mice with transplanted malignant thymoma
Effect of cysteine on the survival of mice with transplanted malignant thymoma
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半胱氨酸对恶性胸腺瘤移植小鼠存活的影响
作者：
N. Campbell;P. Reade;B. Radden
Fullmer和Gibson 1在发炎的人体组织中检测到组织胶原酶，Riley和Spillock 2在某些恶性肿瘤中检测到组织胶原酶。Birbeck和Wheatley 3通过对BALB/c小鼠腹水肿瘤细胞侵入腹壁的电子显微镜研究，提出了组织胶原酶在肿瘤扩散中的可能作用。他们报告说，肿瘤细胞似乎正在积极地破坏邻近的正常组织，这表明来自肿瘤细胞的组织破坏酶的活性。Riley和Rilock 2、Campbell 4以及Dresden、Heilman和Schmidt 5发现了人类和动物肿瘤中的胶原酶活性，这促使人们研究胶原酶抑制剂可能对肿瘤疾病传播的影响。Brown和Weller 3报道，严重碱烧伤后不可避免地发生的角膜溃疡是由于内源性产生的胶原酶引起的，可以通过局部应用胶原酶抑制剂溶液（如半胱氨酸）来预防。本研究旨在验证我们的假设，即恶性肿瘤中产生的胶原酶是肿瘤侵袭的一个因素，通过抑制其活性可以实现对恶性肿瘤疾病的抑制。本文报道的初步实验结果表明，半胱氨酸对移植恶性胸腺瘤的动物的存活率有有益的影响。
TISSUE collagenase has been detected in inflamed human tissues by Fullmer and Gibson1, and in some malignant neoplasms by Riley and Peacock2. The possible role of tissue collagenase in neoplastic spread has been suggested by Birbeck and Wheatley3 from an electron microscopic study of the invasion of ascites tumour cells into the abdominal wall of BALB/c mice. They reported that the tumour cells appeared to be actively destroying adjacent normal tissues, which is suggestive of the activity of tissue-destroying enzymes derived from the neoplastic cells. The finding of collagenase activity in human and animal tumours by Riley and Peacock2, Campbell4, and Dresden, Heilman and Schmidt5, prompted a study into the effect that collagenase inhibitors might have on the spread of neoplastic disease. It has been reported by Brown and Weller3 that corneal ulcerations which inevitably occur following severe alkali burns are due to endogenously produced collagenase and that they can be prevented by topical application of solutions of collagenase inhibitors such as cysteine. The present investigation was designed to test our hypothesis that collagenase produced in malignant neoplasms is a factor in neoplastic invasion and that by inhibiting its activity the arrest of a malignant neoplastic disease could be achieved. The results reported here of initial experiments demonstrate the beneficial effects of cysteine on the survival rates of animals into which malignant thymomas were transplanted.