Consequences of serotonin transporter genotype and early adversity on behavioral profile - pathology or adaptation?
Consequences of serotonin transporter genotype and early adversity on behavioral profile - pathology or adaptation?
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DOI：
10.3389/fnins.2010.00187
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发表时间：
2010
影响因子：
4.3
通讯作者：
Sachser N
中科院分区：
文献类型：
--
作者：
Heiming RS;Sachser N
本文综述了不同5-羟色胺转运体（5-HTT）基因型个体的早期逆境是如何塑造行为特征的。在最近的一项关于5-HTT基因敲除小鼠的研究中，Heiming等人模拟了一个“危险环境”，让怀孕和哺乳期的雌性面对陌生雄性的气味线索，这表明了杀死婴儿的风险。在危险的环境中长大会导致后代的焦虑相关行为增加，探索运动减少，这种影响在缺乏5-HTT表达的小鼠中最为明显。我们认为，这些行为特征的改变代表了母亲的适应性效应，有助于个体科普逆境。原则上，这种逆境对行为特征的影响不应自动被视为病态。相反，根据现代进化理论，它们可能代表适应，尽管具有5-HTT基因型的个体对逆境的易感性可能有发展病理的风险。
This review focuses on how behavioral profile is shaped by early adversity in individuals with varying serotonin transporter (5-HTT) genotype. In a recent study on 5-HTT knockout mice Heiming et al. simulated a ‘dangerous environment‘ by confronting pregnant and lactating females with odor cues of unfamiliar males, indicating the risk of infant killing. Growing up in a dangerous environment induced increased anxiety-related behavior and decreased exploratory locomotion in the offspring, the effects being most pronounced in mice lacking 5-HTT expression. We argue that these alterations in behavioral profile represent adaptive maternal effects that help the individuals to cope with adversity. In principle, such effects of adversity on behavioral profile should not automatically be regarded as pathological. Rather and in accordance with modern evolutionary theory they may represent adaptations, although individuals with 5-HTT genotype induced susceptibility to adversity may be at risk of developing pathologies.
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影响因子：
10.6
作者：
Carola, Valeria;Frazzetto, Giovanni;Gross, Cornelius
通讯作者：
Gross, Cornelius
DOI：
10.1097/00004583-199912000-00009
发表时间：
1999-12-01
影响因子：
13.3
作者：
Brown, J;Cohen, P;Smailes, EM
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Smailes, EM
DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
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通讯作者：
Meaney, MJ
影响因子：
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作者：
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影响因子：
3.6
作者：
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