Nutrition and the immune system from birth to old age
Nutrition and the immune system from birth to old age
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DOI：
10.1038/sj.ejcn.1601492
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发表时间：
2002-08-01
影响因子：
4.7
通讯作者：
Chandra, RK
中科院分区：
文献类型：
--
作者：
Chandra, RK
几千年来，食物一直是社会活动的中心，无论是在欢乐的时候还是在悲伤的时候。蛋白质能量营养不良与细胞介导免疫、吞噬细胞功能、补体系统、分泌性免疫球蛋白a抗体浓度和细胞因子产生的显著损害有关。单一营养素的缺乏也会导致免疫反应的改变：即使在相对轻微的缺乏状态下也会观察到这一点。微量元素中，锌、硒、铁、铜、维生素A、C、E、B-6和叶酸对免疫反应有重要影响。营养过剩和肥胖也会降低免疫力。低出生体重婴儿的细胞介导免疫功能受损时间较长，通过补充额外的锌可以部分恢复。在老年人中，受损的免疫力可以通过适量的微量营养素组合来增强。这些发现具有相当大的实际意义和公共卫生意义。
For millennia, food has been at the center of social events, in times of joy and in times of sorrow. Protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production. Deficiency of single nutrients also results in altered immune response: this is observed even when the deficiency state is relatively mild. Of the micronutrients, zinc, selenium, iron, copper, vitamins A, C, E and B-6, and folic acid have important influences on immune responses. Overnutrition and obesity also reduce immunity. Low-birth-weight infants have a prolonged impairment of cell-mediated immunity that can be partly restored by providing extra amounts of dietary zinc. In the elderly, impaired immunity can be enhanced by modest amounts of a combination of micronutrients. These findings have considerable practical and public health significance.