Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures
Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures
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DOI：
10.1111/acel.13105
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发表时间：
2020-01-22
期刊：
影响因子：
7.8
通讯作者：
Nielsen, Dennis S.
中科院分区：
文献类型：
--
作者：
Castro-Mejia, Josue L.;Khakimov, Bekzod;Nielsen, Dennis S.
当人类变老时，身体成分的变化会沿着与生活方式相关的疾病，影响健康和身体衰退。在这里，我们提供了一个全面的观点，饮食摄入量，身体活动，肠道微生物群（GM）和宿主代谢组与207名年龄在65岁以上的社区居民的身体健康。分层人体测量/身体成分/体能测量（ABPm）变量确定了两种表型（高/低健身）明确联系到饮食摄入量，体力活动，GM和主机代谢组模式。引人注目的是，尽管能量摄入量较高，但高健康受试者的特征在于更瘦的身体和更低的空腹胰岛素原-C-肽/血糖水平，其机制可能是由更高的膳食纤维摄入量、体力活动和GM和相关代谢物中双歧杆菌目和梭菌目物种的丰度增加（即，肠内酯）。这些因素可以解释体质个体差异的50.1%。我们建议，针对调节GM和宿主代谢组相互作用的饮食策略可能允许建立治疗方法来延迟并可能逆转衰老的合并症。
When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging.