Individual Common Carotid Artery Wall Layer Dimensions, but Not Carotid Intima-Media Thickness, Indicate Increased Cardiovascular Risk in Women With Preeclampsia An Investigation Using Noninvasive High-frequency Ultrasound
Individual Common Carotid Artery Wall Layer Dimensions, but Not Carotid Intima-Media Thickness, Indicate Increased Cardiovascular Risk in Women With Preeclampsia An Investigation Using Noninvasive High-frequency Ultrasound
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DOI：
10.1161/circimaging.113.000295
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发表时间：
2013-09-01
影响因子：
7.5
通讯作者：
Naessen, Tord
中科院分区：
文献类型：
--
作者：
Akhter, Tansim;Wikstrom, Anna-Karin;Naessen, Tord
背景子痫前期（PE）与生命后期心血管疾病的风险增加有关。超声评估颈总动脉内膜-中膜厚度（IMT）在PE期间或之后没有显示任何心血管风险增加。方法和结果我们使用高频超声（22 MHz）估计55例PE诊断妇女和64例相似阶段正常妊娠妇女的颈总动脉imt。所有患者均于产后1年左右复查。内膜厚、中膜薄、内膜/中膜（I/M）比值高是动脉壁不健康的标志。与正常妊娠相比，PE与颈总动脉内膜增厚、中膜变薄、I/M比值升高相关(平均I/M差值为0.21；95%可信区间为0.17-0.25
Background Preeclampsia (PE) is associated with increased risk of cardiovascular disease later in life. Ultrasound assessment of the common carotid artery intima-media thickness (IMT) during or after PE has not indicated any increased cardiovascular risk.Methods and Results We used high-frequency ultrasound (22 MHz) to estimate the individual common carotid artery IMTs in 55 women at PE diagnosis and in 64 women with normal pregnancies at a similar stage. All were re-examined about 1 year postpartum. A thick intima, thin media, and high intima/media (I/M) ratio are signs of a less healthy artery wall. PE was associated with a significantly thicker mean common carotid artery intima, thinner media, and higher I/M ratio than in normal pregnancy (mean I/M difference, 0.21; 95% confidence interval, 0.17-0.25; P