Animal Models of Hypertension: A Scientific Statement From the American Heart Association
Animal Models of Hypertension: A Scientific Statement From the American Heart Association
复制标题
DOI：
10.1161/hyp.0000000000000090
复制
发表时间：
2019-06-01
期刊：
影响因子：
8.3
通讯作者：
Coffman, Thomas M.
中科院分区：
文献类型：
--
作者：
Lerman, Lilach O.;Kurtz, Theodore W.;Coffman, Thomas M.
高血压是世界上最常见的慢性疾病，但血压升高的确切原因往往无法确定。动物模型对于揭示高血压的发病机制和测试新的治疗策略是有用的。动物模型用于提高对高血压及其合并症的发病机制、预防和治疗的理解的效用取决于它们代表人类高血压形式的有效性，包括对治疗的反应，以及这些模型中研究的质量（如再现性和实验设计）。在这一领域重要的未满足的需求，包括模拟离散的高血压综合征，现在填充的临床模型的发展，在高血压的发病机制的持续争议的解决方案，和预防和治疗高血压及其并发症的新途径的发展。动物模型可能确实有助于解决这些未满足的需求。
Hypertension is the most common chronic disease in the world, yet the precise cause of elevated blood pressure often cannot be determined. Animal models have been useful for unraveling the pathogenesis of hypertension and for testing novel therapeutic strategies. The utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy, and on the quality of studies in those models (such as reproducibility and experimental design). Important unmet needs in this field include the development of models that mimic the discrete hypertensive syndromes that now populate the clinic, resolution of ongoing controversies in the pathogenesis of hypertension, and the development of new avenues for preventing and treating hypertension and its complications. Animal models may indeed be useful for addressing these unmet needs.