Assessment of lymph node metastases by contrast-enhanced MR imaging in a head and neck cancer model
Assessment of lymph node metastases by contrast-enhanced MR imaging in a head and neck cancer model
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DOI：
10.3348/kjr.2007.8.1.9
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发表时间：
2007-01-01
影响因子：
4.8
通讯作者：
Chang, Kee-Hyun
中科院分区：
文献类型：
--
作者：
Lee, Ki Chang;Moon, Woo Kyung;Chang, Kee-Hyun
目的：我们要探讨的准确性，对比增强MR成像检测淋巴结转移瘤在头颈部癌兔model.Materials和方法：转移淋巴结模型，我们使用的是创建的六个新西兰白色兔耳的TSVX2肿瘤。在肿瘤细胞接种后3周，在注射钆喷酸葡胺之前和之后获得T1加权MR图像。大小、信号强度比（即，36个区域淋巴结的增强模式对腮腺和下颌尾侧淋巴结的MRI表现进行了评价，并与病理结果进行了比较。12个转移性淋巴结（10.51 ± 3.2mm）与24个增生性淋巴结（8.0 ± 3.6mm）大小无统计学差异（P> 0.05）。增强T1WI上，9个转移性淋巴结和4个增生性淋巴结呈周边高信号，中心低信号，3个转移性淋巴结和20个增生性淋巴结呈均匀高信号。以信号强度比小于1作为诊断淋巴结转移的标准，增强扫描的敏感性为75%（9/12），特异性为83%（20/24），阳性预测值为69%（9/13），阴性预测值为87%（20/23）。受试者工作特征曲线下面积为0.81。本实验研究证实，转移性和增生性淋巴结可以区分使用MR图像的基础上的造影剂摄取模式，但是不能使用任何特定的尺寸标准来区分它们。
Objective: We wanted to investigate the accuracy of contrast-enhanced MR imaging for the detection of lymph node metastases in a head and neck cancer rabbit model.Materials and Methods: The metastatic lymph node model we used was created by inoculating VX2 tumors into the auricles of six New Zealand White rabbits. T1-weighted MR images were obtained before and after injecting gadopentetate dimeglumine at three weeks after tumor cell inoculation. The sizes, signal intensity ratios (i.e., the postcontrast signal intensities of the affected nodes relative to the adjacent muscle) and the enhancement patterns of 36 regional lymph nodes (parotid and caudal mandibular nodes) were evaluated on MR images and then compared with the histopathologic findings.Results: No statistical difference was found between the sizes of 12 metastatic (10.5 1 +/- 3.2 mm) and 24 hyperplastic (8.0 +/- 3.6 mm) lymph nodes (p > 0.05). On the contrast-enhanced T1-weighted MR images, nine metastatic and four hyperplastic lymph nodes had peripheral high and central low signal intensity, whereas three metastatic and 20 hyperplastic lymph nodes had homogeneous high signal intensity. Using a signal intensity ratio less than one as a diagnostic criterion for a metastatic lymph node, the sensitivity, specificity and positive and negative predictive values of the enhanced MR images were 75% (9/12), 83% (20/24), 69% (9/13) and 87% (20/23), respectively, with areas under receiver-operating-characteristic curve values of 0.81.Conclusion: This experimental study confirms that metastatic and hyperplastic lymph nodes can be differentiated using MR images on the basis of the contrast uptake patterns, but that they cannot be differentiated using any particular size criteria.