Strategies Developed by Toxoplasma gondii to Survive in the Host
Strategies Developed by Toxoplasma gondii to Survive in the Host
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弓形虫在宿主体内生存的策略
DOI：
10.3389/fmicb.2019.00899
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发表时间：
2019
影响因子：
5.2
通讯作者：
Yu Li
中科院分区：
文献类型：
--
作者：
Zhu Wanbo;Li Jingyang;Pappoe Faustina;Shen Jilong;Yu Li
作为最成功的细胞内寄生虫之一，弓形虫已经发展了几种策略来避免被宿主破坏。这些方法包括快速有效的细胞侵入以避免吞噬细胞吞噬，经典CD 40-CD 40 L介导的自噬途径的负调节，非经典IFN-γ依赖性自噬途径的损伤，以及调节宿主细胞存活和死亡以获得终身寄生虫存活。不同的病毒株甚至进化出不同的方式来科普和逃避宿主的破坏。本文对弓形虫感染过程中宿主与弓形虫之间的博弈作一综述。更好地了解弓形虫与其宿主之间战斗的各个方面将有助于开发更好的策略和药物来控制寄生虫。
One of the most successful intracellular parasites, Toxoplasma gondii has developed several strategies to avoid destruction by the host. These include approaches such as rapid and efficient cell invasion to avoid phagocytic engulfment, negative regulation of the canonical CD40-CD40L-mediated autophagy pathway, impairment of the noncanonical IFN-γ-dependent autophagy pathway, and modulation of host cell survival and death to obtain lifelong parasite survival. Different virulent strains have even evolved different ways to cope with and evade destruction by the host. This review aims to illustrate every aspect of the game between the host and Toxoplasma during the process of infection. A better understanding of all aspects of the battle between Toxoplasma and its hosts will be useful for the development of better strategies and drugs to control the parasite.